Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications
Juan Carlos Palomeque Chávez, Matthew McGrath, Cian O’Connor, Adrian Dervan, James E. Dixon, Cathal J. Kearney, S. Browne, Fergal J. O’Brien
Abstract
models. Taken together, the VEGF-activated scaffold demonstrates multifaceted outcomes through the induction of pro-angiogenic and neurogenic responses from dermal, vascular and neural cells, illustrating the potential of this platform for the healing of chronic wounds.
Topics & Concepts
AngiogenesisWound healingScaffoldNeuriteVEGF receptorsChemistryVascular endothelial growth factorChronic woundNeuroscienceCell biologyMedicineCancer researchBiomedical engineeringBiologySurgeryBiochemistryIn vitroElectrospun Nanofibers in Biomedical ApplicationsWound Healing and Treatments