The A allele of the rs759853 single nucleotide polymorphism in the AKR1B1 gene confers risk for diabetic kidney disease in patients with type 2 diabetes from a Brazilian population
Cristine Dieter, Natália Emerim Lemos, Nathalia Rodrigues de Faria Corrêa, Felipe Mateus Pellenz, Luís Henrique Canani, Daisy Crispim, Andrea Carla Bauer
Abstract
OBJECTIVE: gene and DKD. METHODS: The sample comprised 695 patients with type 2 DM (T2DM) and DKD (cases) and 310 patients with T2DM of more than 10 years' duration, but no DKD (controls). The polymorphism was genotyped by real-time PCR. RESULTS: Allelic and genotype frequencies of this polymorphism did not differ significantly between groups. However, the A/A genotype was associated with risk for DKD after adjustment for gender, triglycerides, BMI, presence of hypertension and diabetic retinopathy, and duration of DM, under both recessive (P = 0.048) and additive (P = 0.037) inheritance models. CONCLUSION: rs759853A/A genotype and risk for DKD in Brazilians T2DM patients.