Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Adults in an Open-Label Phase 1 Multiple Ascending Dose and Food Effect Study
Thanh Bach, Shirley Galbiati, Jessie K. Kennedy, Gregory A. Deye, Effie Nomicos, Ellen E. Codd, Héctor H. Garcı́a, John Horton, Robert H. Gilman, Armando E. González, Patricia Winokur, Guohua An
Abstract
Neurocysticercosis and trichuriasis are difficult-to-treat parasitic infections that affect more than 1.5 billion people worldwide. Oxfendazole, a potent broad-spectrum benzimidazole anthelmintic approved for use in veterinary medicine, has shown substantial antiparasitic activity against neurocysticercosis and intestinal helminths in preclinical studies. As part of a program to transition oxfendazole from veterinary medicine to human use, phase I multiple ascending dose and food effect studies were conducted.
Topics & Concepts
PharmacokineticsTolerabilityOpen labelMedicinePharmacologyAdverse effectInternal medicineHelminth infection and controlParasites and Host InteractionsParasitic Diseases Research and Treatment