Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance
June‐Young Lee, Venugopal Reddy Venna, David J. Durgan, Huanan Shi, Jacob Hudobenko, Nagireddy Putluri, Joseph F. Petrosino, Louise D. McCullough, Robert M. Bryan
Abstract
= .030) tests, respectively. We conclude that an aged microbiome alone is sufficient to decrease SCFAs in the host and to produce cognitive decline.
Topics & Concepts
ButyrateMicrobiomeBiologyFecesCognitive declineEnvironmental enrichmentShort-chain fatty acidGut–brain axisPhysiologyPropionateImmunologyEndocrinologyInternal medicineMicrobiologyDiseaseBioinformaticsBiochemistryMedicineDementiaFermentationGut microbiota and healthGastrointestinal motility and disordersClostridium difficile and Clostridium perfringens research