Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter
Tristan Rawling, Hugo MacDermott-Opeskin, Ariane Roseblade, Curtis Pazderka, Callum Clarke, Kirsi Bourget, Xin Wu, William Lewis, Benjamin B. Noble, Philip A. Gale, Megan L. O’Mara, Charles G. Cranfield, Michael T. Murray
Abstract
A new mitochondrial uncoupler that forms membrane permeable dimers through interactions of remote acidic and anion receptor groups.
Topics & Concepts
Inner mitochondrial membraneTransporterMitochondrionChemistryArylUreaMembraneIonBiochemistryStereochemistryOrganic chemistryGeneAlkylMolecular Sensors and Ion DetectionMitochondrial Function and PathologySupramolecular Chemistry and Complexes