Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
Alberto Cagigi, Karin Loré
Abstract
In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.
Topics & Concepts
Immune systemVaccinationMessenger RNAImmunologyBiologyInnate immune systemAcquired immune systemVirologyMedicineGeneticsGeneRNA Interference and Gene DeliverySARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune Responses