Sulfilimines: An Underexplored Bioisostere for Drug Design?
Per I. Arvidsson
Abstract
Sulfilimines have so far received little attention as a bioisostere for sulfoxides in the design of biologically active compounds. A recent study on physicochemical and in vitro drug-like properties shows that sulfilimines deserve a place in the medicinal chemist's toolbox.
Topics & Concepts
BioisostereChemistryToolboxDrugPharmacologyChemistCombinatorial chemistryIn vitroOrganic chemistryMedicineBiochemistryComputer scienceChemical synthesisProgramming languageSynthesis and Catalytic ReactionsSulfur-Based Synthesis TechniquesClick Chemistry and Applications