The cross-talk between B cells and macrophages
Yahui Su, Siyi Liu, Chen Long, Zihua Zhou, Yanhong Zhou, Jingqiong Tang
Abstract
• Subcapsular sinus macrophages (SSMs) play different roles in different diseases. In transplantation, the activation of B cells by SSMs is not conducive to the survival of grafts. In some tumors. SSMs exert anti-tumor effects by inhibiting B cell activation. It is worth considering whether there is a selective expansion or depletion of SSMs to regulate the activation of B cells to control disease. • B cells create an environment conducive to disease treatment by regulating the polarization of macrophages. In the case of infection or cancer, blocking B cells to polarize macrophages to M2 phenotype or promoting B cells to polarize macrophages to M1 phenotype can promote immune response. In the case of inflammation, promoting B-cell polarized macrophages to M2 phenotype will have an anti-inflammatory effect. • There are 10 mechanisms such as CCL / CCR, IL-32B / BAFF, CD47 / SIRPA and so on, which can make readers clearly understand the mutual regulation relationship and specific mechanism between macrophages and B cells, and facilitate a comprehensive and systematic understanding of the interaction between these two immune cells so as to provide ideas for the treatment of diseases. • B cell-derived extracellular vesicles (EVs) cooperate with macrophages by carrying miRNAs (e.g., BART miRNA), proteins (e.g., PD-L1, NSE), and lipid (e.g., PS) to establish a B-cell malignant tumor-friendly microenvironment. Inhibiting the release of EVs provides new ideas for future treatment. B cells and macrophages are significant immune cells that maintain the immune balance of the body. B cells are involved in humoral immunity, producing immune effects mainly by secreting antibodies. Macrophages participate in non-specific and specific immune responses. To gain a further understanding of macrophages and B cells, researchers have not only paid attention to the unidirectional influence between B cells and macrophages, but also have focused on the cross-talk between them, and the effect of this cross talk on diseases. Therefore, this review summarizes the influence of macrophages on B cells, the ways and mechanisms by which B cells affect macrophages, and their cross-talk, leading to a more comprehensive understanding of the mechanism of the interaction between macrophages and B cells.