Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders
Huirong Lin, Yu Zhou, Jiaming Wang, Huimeng Wang, Tianhong Yao, Hu Chen, Huili Zheng, Yang Zhang, En Ren, Lai Jiang, Chengchao Chu, Xiaoyuan Chen, Jingsong Mao, Fudi Wang, Gang Liu
Abstract
SIR changes in animal models. ICG/Leci also promoted a 100% increase in iron depletion in the liver compared with deferoxamine. The high MR sensitivity and superior photoacoustic contrast, combined with enhanced iron depletion, demonstrate that ICG/Leci is a promising theranostic agent for simultaneous detection and treatment of iron-overload disorders.
Topics & Concepts
RepurposingMedicineBiologyEcologyIron Metabolism and DisordersAdvanced MRI Techniques and ApplicationsHemoglobinopathies and Related Disorders