Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis
Yihong Huang, Shuo Zheng, Ying Lin, Liming Ke
Abstract
. Mechanically, circ-ERBB2 sponged microRNA 136-5p (miR-136-5p) to elevate pyruvate dehydrogenase kinase 4 (PDK4) expression. In conclusion, circ-ERBB2 facilitated the Warburg effect and malignancy of TNBC cells by the miR-136-5p/PDK4 pathway, at least in part. This study supports circ-ERBB2 as a prognostic indicator for TNBC.
Topics & Concepts
Triple-negative breast cancerGene knockdownWarburg effectCancer researchmicroRNABiologyBreast cancerCancerMolecular biologyApoptosisCancer cellGeneGeneticsBiochemistryCircular RNAs in diseasesMicroRNA in disease regulationGenomics, phytochemicals, and oxidative stress