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Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles From Giardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells

Bruno Gavinho, Bruna Sabatke, Verônica Feijoli Santiago, Izadora Volpato Rossi, Janaína Macedo da Silva, Ingrid Evans‐Osses, Giuseppe Palmisano, Sigrun Lange, Marcel I. Ramirez

2020Frontiers in Cellular and Infection Microbiology77 citationsDOIOpen Access PDF

Abstract

. Our results suggest that LEVs and SEVs have a different role in host-pathogen interaction, and that treatment with EV-inhibitors may be a novel treatment strategy for recurrent giardiasis.

Topics & Concepts

GiardiaPathogenBiologyMicrobiologyExtracellularVirulencePopulationGiardia lambliaCell biologyBiochemistryGeneDemographySociologyParasitic Infections and DiagnosticsToxoplasma gondii Research StudiesAmoebic Infections and Treatments
Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles From Giardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells | Litcius