Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content
Lianmin Chen, Inge van den Munckhof, Kiki Schraa, Rob ter Horst, Martijn Koehorst, Martijn van Faassen, Claude van der Ley, Marwah Doestzada, Daria V. Zhernakova, Alexander Kurilshikov, Vincent W. Bloks, Albert K. Groen, Niels P. Riksen, Joost H.W. Rutten, Leo A. B. Joosten, Cisca Wijmenga, Alexandra Zhernakova, Mihai G. Netea, Jingyuan Fu, Folkert Kuipers
Abstract
) and 439 microbial correlations (FDR < 0.05) for 50 BA entities. Additionally, we report 111 correlations between BA and 88 lipid parameters (FDR < 0.05), mainly for C4 reflecting hepatic BA synthesis. Inter-individual variability in the plasma BA profile does not reflect hepatic BA synthetic pathways, but rather transport and metabolism within the enterohepatic circulation. Our study reveals genetic and microbial determinants of BAs in obesity and their relationship to disease-relevant lipid parameters that are important for the design of personalized therapies targeting BA-signaling pathways.