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Design, synthesis and biological evaluation of novel diazaspirodecanone derivatives containing piperidine-4-carboxamide as chitin synthase inhibitors and antifungal agents

Qinggang Ji, Bing Li, Yiwen Chu, Hu Wu, Chuanbiao Du, Yajie Xu, Yangli Shen, Junfeng Deng

2021Bioorganic Chemistry14 citationsDOI

Topics & Concepts

ChemistryCandida albicansIC50ChitinFluconazoleCryptococcus neoformansStereochemistryPotencyMinimum inhibitory concentrationChitin synthaseATP synthaseAntifungalIn vitroEnzymeBiochemistryMicrobiologyChitosanBiologyCarbohydrate Chemistry and SynthesisStudies on Chitinases and ChitosanasesFungal Plant Pathogen Control
Design, synthesis and biological evaluation of novel diazaspirodecanone derivatives containing piperidine-4-carboxamide as chitin synthase inhibitors and antifungal agents | Litcius