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Microbial electrosynthetic nitrate reduction to ammonia by reversing the typical electron transfer pathway in Shewanella oneidensis

Yao Li, Sen Qiao, Meiwei Guo, Caiyun Hou, Jingxuan Wang, Cong Yu, Jiti Zhou, Xie Quan

2023Cell Reports Physical Science23 citationsDOIOpen Access PDF

Abstract

Ammonia production is a critical industrial process, and mild routes to recycle nitrates in wastewater could be a promising route to ammonia synthesis. In this study, ammonia production is demonstrated in a microbial electrosynthesis system with nitrate and an electrode as electron acceptors and donors, respectively. Based on the bidirectional extracellular electron transfer capability of Shewanella oneidensis MR-1, our microbial electrosynthetic system achieves a maximum ammonia production rate of 24.3 μg h−1·mg protein−1 with 82.5% selectivity and 33.1% cathodic efficiency and functions for several cycles over 30 days. Electrochemical analysis suggests that cytochromes c, flavins, and the flavin/c-cytochrome combination play a pivotal role. Charge transfer resistance weakens over the course of weeks, resulting in easier electron transfer. Parallel reaction monitoring proteomics suggest that reversing a typical “Mtr pathway” plays a role, and a dissimilatory nitrate to ammonia pathway is used. This work proposes a progressive route to carry out ammonia synthesis under mild conditions.

Topics & Concepts

Shewanella oneidensisChemistryAmmoniaElectron transferNitrateAmmonia productionElectron acceptorFlavin groupNitriteRedoxInorganic chemistryPhotochemistryBiochemistryBacteriaOrganic chemistryEnzymeGeneticsBiologyMicrobial Fuel Cells and BioremediationAmmonia Synthesis and Nitrogen ReductionWastewater Treatment and Nitrogen Removal
Microbial electrosynthetic nitrate reduction to ammonia by reversing the typical electron transfer pathway in Shewanella oneidensis | Litcius