Qdenga® - A promising dengue fever vaccine; can it be recommended to non-immune travelers?
Martin Angelin, Jan Sjölin, Fredrik Kahn, Anna Ljunghill Hedberg, Anja Rosdahl, Paul Skorup, S. Benson Werner, Susanne Woxenius, Helena Hervius Askling
Abstract
Qdenga® has been approved by the European Medicines Agency (EMA) for individuals > 4 years of age and for use according to national recommendations. The vaccine shows high efficacy against virologically confirmed dengue and severe dengue in clinical studies on 4-16-year old's living in endemic areas. For individuals 16-60 years old only serological data exists and there is no data for individuals > 60 years. Its use as a travel vaccine is still unclear. We present the studies behind the approval and the recommendations for travelers as issued by the Swedish Society for Infectious Diseases Physicians.