Reconstitution of Bam Complex-Mediated Assembly of a Trimeric Porin into Proteoliposomes
Sunyia Hussain, Janine H. Peterson, Harris D. Bernstein
Abstract
Porins are a widespread family of homotrimers that represent a substantial fraction of the total protein located in the OM of many proteobacteria. These proteins facilitate the nonspecific diffusion of small molecules across the outer membrane and strongly influence the susceptibility of bacteria to clinically used antibiotics.
Topics & Concepts
PorinChemistryComputational biologyBiologyBiochemistryBacterial outer membraneEscherichia coliGeneRNA Interference and Gene DeliveryLipid Membrane Structure and BehaviorSupramolecular Self-Assembly in Materials