In vivo techniques for assessment of insulin sensitivity and glucose metabolism
Margaret Hahn, Adria Giacca, Sandra Pereira
Abstract
Metabolic tests are vital to determine in vivo insulin sensitivity and glucose metabolism in preclinical models, usually rodents. Such tests include glucose tolerance tests, insulin tolerance tests, and glucose clamps. Although these tests are not standardized, there are general guidelines for their completion and analysis that are constantly being refined. In this review, we describe metabolic tests in rodents as well as factors to consider when designing and performing these tests.
Topics & Concepts
Insulin sensitivityCarbohydrate metabolismIn vivoInsulinGlucose tolerance testMedicineBiologyInsulin resistanceEndocrinologyBiotechnologyAdipose Tissue and MetabolismPancreatic function and diabetesMetabolism, Diabetes, and Cancer