LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK
Gong Zhang, Ximin Chen, Lei Ma, Rui Ding, Lihong Zhao, Feng Ma, Xubin Deng
Abstract
study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cell proliferation and cell migration were identified using RNA-sequence. Subsequently, it was confirmed that LINC01419 binds to EZH2, leading to histone methylation of the RECK promoter. Interaction between LINC01419 and FUS stabilized EZH2 mRNA thereby enhancing EZH2 expression. Conclusively, the results of this study confirm that LINC01419 may serve as a potential target for HCC diagnosis and treatment.
Topics & Concepts
EZH2Cancer researchHepatocellular carcinomaLong non-coding RNACarcinogenesisMethylationMetastasisBiologyHistoneCell growthCell cultureRNAGeneGeneticsCancerCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing