Post-synthesis of a titanium-rich magnetic COF nanocomposite with flexible branched polymers for efficient enrichment of phosphopeptides from human saliva and serum
Luyan Meng, Bing Wang, Baichun Wang, Quanshou Feng, Sijia Zhang, Sijia Zhang, Zi Xiong, Shun Zhang, Shun Zhang, Ting Cai, Chuan‐Fan Ding, Yinghua Yan
Abstract
, 16 endogenous phosphopeptides from fresh saliva of healthy people were recognized by MALDI-TOF MS, and 50 phosphopeptides belonging to 35 phosphoproteins from the serum of uremia patients were detected by nano-LC-MS/MS. Proteomics data analysis for the differential protein selection between uremia and normal controls was conducted using R software, and four down-regulated and three up-regulated proteins were obtained. The results suggested that the prepared material has potential applications in biomarker discovery.
Topics & Concepts
NanocompositeCovalent bondPolymerTitaniumChemistryChemical engineeringSalivaPolymer chemistryMaterials scienceNanotechnologyOrganic chemistryBiochemistryEngineeringCovalent Organic Framework ApplicationsMetal-Organic Frameworks: Synthesis and ApplicationsLuminescence and Fluorescent Materials