Cannabinoids and drug metabolizing enzymes: potential for drug-drug interactions and implications for drug safety and efficacy
Keti Bardhi, Shelby Coates, Christy J.W. Watson, Philip Lazarus
Abstract
INTRODUCTION: Cannabis is an increasingly popular recreational and medicinal drug in the USA. While cannabis is still a Schedule 1 drug federally, many states have lifted the ban on its use. With its increased usage, there is an increased possibility for potential drug-drug interactions (DDI) that may occur with concomitant use of cannabis and pharmaceuticals. AREA COVERED: investigations, current research suggests that cannabis exhibits the potential to induce DDI under certain circumstances. EXPERT OPINION: Based upon the current literature, there is a strong potential for cannabis-induced DDI among major drug-metabolizing enzymes.
Topics & Concepts
DrugPharmacologyCannabisMedicineApproved drugPsychiatryCannabis and Cannabinoid ResearchForensic Toxicology and Drug AnalysisPsychedelics and Drug Studies