Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters
Jens Pahnke, Pablo Bascuñana, Mirjam Brackhan, Katja Stefan, Vigneshwaran Namasivayam, Radosveta Koldamova, Jingyun Wu, Luisa Möhle, Sven Marcel Stefan
Abstract
methodologies to gain novel templates for the development of innovative ABC transporter-targeting diagnostics and therapeutics.
Topics & Concepts
ABCC1ATP-binding cassette transporterAbcg2BiologyEffluxTransporterSolute carrier familyPhenotypic screeningIn silicoSubfamilyComputational biologyPhenotypeGeneticsGeneDrug Transport and Resistance MechanismsCholesterol and Lipid MetabolismComputational Drug Discovery Methods