Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements
Tiffany Amariuta, Kazuyoshi Ishigaki, Hiroki Sugishita, Tazro Ohta, Masaru Koido, Kushal K. Dey, Koichi Matsuda, Yoshinori Murakami, Alkes L. Price, Eiryo Kawakami, Chikashi Terao, Soumya Raychaudhuri
Topics & Concepts
BiologySoftware portabilityHeritabilitySNPGeneticsQuantitative trait locusTraitComputational biologyGenetic associationPrioritizationEpigeneticsEvolutionary biologyGenome-wide association studySingle-nucleotide polymorphismGeneGenotypeComputer scienceEconomicsProgramming languageManagement scienceGenetic Associations and EpidemiologyEpigenetics and DNA MethylationGenomics and Chromatin Dynamics