A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus
Zutao Yu, Mengting Ai, Soumen K. Samanta, Fumitaka Hashiya, Junichi Taniguchi, Sefan Asamitsu, Shuji Ikeda, Kaori Hashiya, Toshikazu Bando, Ganesh N. Pandian, Lyle Isaacs, Hiroshi Sugiyama
Abstract
We developed an epigenetically active, cooperative DNA binding transcription factor platform assisted by cucurbit[7]uril (CB7) host-guest modules. This new type of molecule termed ePIP-HoGu not only mimics the operation of transcription factors as a pair but also recruits the epigenetic modifier to a particular DNA locus.
Topics & Concepts
EpigeneticsLocus (genetics)DNATranscription factorGeneticsComputational biologyDNA methylationBiologyChemistryGeneGene expressionSupramolecular Chemistry and ComplexesAdvanced biosensing and bioanalysis techniquesSupramolecular Self-Assembly in Materials