Neurodevelopmental Toxicity of Polystyrene Nanoplastics in<i>Caenorhabditis elegans</i>and the Regulating Effect of Presenilin
Qianyun Liu, Chunxiang Chen, Mengting Li, Jia Ke, Yichen Huang, Yuefeng Bian, Shufen Guo, Yang Wu, Yan Han, Mingyuan Liu
Abstract
were involved in regulation of PS-NP-induced neurodevelopmental toxicity and mitochondrial damage. In conclusion, PS-NPs could induce neurodevelopmental toxicity dependent on particle sizes mediated by mitochondrial damage and DA reduction. Enhanced expression of presenilin plays a role in PS-NP-induced oxidative stress and neurodevelopmental toxicity.
Topics & Concepts
ToxicityCaenorhabditis elegansOxidative stressChemistryNeurotoxicityReactive oxygen speciesBiophysicsCell biologyApoptosisMitochondrionBiochemistryBiologyGeneOrganic chemistryMicroplastics and Plastic PollutionNanoparticles: synthesis and applicationsGraphene and Nanomaterials Applications