Cooperative catalysis-enabled C–N bond cleavage of biaryl lactams with activated isocyanides
Wen-Tao Wang, Sen Zhang, Ling‐Fei Tao, Ziqi Pan, Linghui Qian, Jia‐Yu Liao
Abstract
The catalytic reaction of biaryl lactams with activated isocyanides is reported for the first time. By employing a cooperative catalytic system, oxazole-containing axially chiral biaryl anilines were obtained in high yields with excellent enantioselectivities. The key to the success lies in the atroposelective amide C-N bond cleavage with activated isocyanides.
Topics & Concepts
OxazoleCatalysisChemistryCleavage (geology)AmideCombinatorial chemistryPeptide bondBond cleavageStereochemistryMedicinal chemistryPeptideOrganic chemistryMaterials scienceBiochemistryFracture (geology)Composite materialAxial and Atropisomeric Chirality SynthesisChemical synthesis and alkaloidsAlkaloids: synthesis and pharmacology