<i>N</i>- and <i>O</i>-arylation of pyridin-2-ones with diaryliodonium salts: base-dependent orthogonal selectivity under metal-free conditions
Masami Kuriyama, Natsumi Hanazawa, Yusuke Abe, Kotone Katagiri, Shimpei Ono, Kosuke Yamamoto, Osamu Onomura
Abstract
-arylation reactions smoothly proceeded with the use of quinoline in chlorobenzene, leading to high yields and selectivities. In these methods, a variety of pyridin-2-ones in addition to pyridin-4-one and a set of diaryliodonium salts were accepted as suitable reaction partners.
Topics & Concepts
ChemoselectivityBase (topology)ChemistryBase metalMetalSelectivityFree baseCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCatalysisMaterials scienceMathematicsSalt (chemistry)MetallurgyWeldingMathematical analysisCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsOxidative Organic Chemistry Reactions