Litcius/Paper detail

Indol‐2‐ylidene (IdY): Ambiphilic N‐Heterocyclic Carbene Derived from Indole**

Hyunho Kim, Minseop Kim, Hayoung Song, Eunsung Lee

2020Chemistry - A European Journal18 citationsDOI

Abstract

Abstract The synthesis of ambiphilic N‐heterocyclic carbene ligand, indol‐2‐ylidene (IdY, A ), is described. A series of indolenium precursors ( 2 a – f ) were prepared on a gram scale in good yields. Trapping experiments with elemental selenium, [RhCl(cod)] 2 and CuCl provided the expected carbene adducts. Further computational and spectroscopic studies supported the ambiphilicity of IdY, which lies between cyclic (alkyl)(amino)carbenes (CAAC‐5) and cyclic (amino)(aryl)carbene (CAArC). The copper complexes ( 6 ) show high percent buried volume (% V bur = 58.1) and allow for carboboration of terminal alkynes within 30 minutes in a demonstration of synthetic utility with good yields and high regioselectivity.

Topics & Concepts

CarbeneRegioselectivityArylChemistryAlkylIndole testAdductMedicinal chemistryStereochemistryOrganic chemistryCatalysisN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods