Monkeypox Virus Evolution before 2022 Outbreak
Eric Dumonteil, Claudia Herrera, Gilberto Sabino‐Santos
Abstract
Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3) deaminase editing. This microevolutionary pattern most likely reflects community spread of the virus and adaptation to humans.
Topics & Concepts
MonkeypoxOutbreakBiologyVirusVirologyPhylogenetic treePhylogeneticsGenomeCytidine deaminaseGeneticsEvolutionary biologyGeneVacciniaRecombinant DNAPoxvirus research and outbreaksBacillus and Francisella bacterial researchRabies epidemiology and control