Cigarette smoke-induced injury induces distinct sex-specific transcriptional signatures in mice tracheal epithelial cells
Baishakhi Ghosh, Pratulya Pragadaraju Chengala, Sonya Shah, Daniel Chen, Vaishnavi Karnam, Kai Wilmsen, Bonnie Yeung‐Luk, Venkataramana K. Sidhaye
2023American Journal of Physiology-Lung Cellular and Molecular Physiology22 citationsDOIOpen Access PDF
Abstract
The study underscores the importance of considering sex-specific differences in the airway epithelium in respiratory diseases such as COPD. Differences in gene expression between males and females at baseline and in response to chronic injury in the airway epithelium could have implications on disease susceptibility, both in COPD and other respiratory diseases. Therefore, understanding these differences is crucial for developing targeted therapies to treat respiratory diseases based on a sex-specific manner.
Topics & Concepts
Context (archaeology)TranscriptomeBiologyImmunologyRespiratory systemPhysiologyMedicineGeneticsGeneGene expressionAnatomyPaleontologyNeonatal Respiratory Health ResearchAsthma and respiratory diseasesEpigenetics and DNA Methylation