Kaempferol-3-<i>O</i>-rutinoside, a flavone derived from<i>Tetrastigma hemsleyanum</i>, suppresses lung adenocarcinoma<i>via</i>the calcium signaling pathway
Yonglu Li, Xin Yu, Yaxuan Wang, Xiaodong Zheng, Qiang Chu
Abstract
-rutinoside (K3R), the major component of THTF, effectively triggered cytoskeleton collapse, mitochondrial dysfunction and consequent calcium overload to achieve apoptosis, which remained consistent with proteomic results. This study uncovers a new mechanism for THTF anti-tumor ability, and suggests THTF and K3R as promising anti-cancer agents, providing new ideas and possible strategies for future anti-lung cancer prevention and therapy.
Topics & Concepts
Lung cancerCytoskeletonApoptosisAdenocarcinomaSignal transductionIn vivoKaempferolCalciumViability assayCancer researchChemistryCancerPharmacologyBiologyMedicineCell biologyBiochemistryCellPathologyInternal medicineAntioxidantFlavonoidGeneticsRNA Research and SplicingNatural product bioactivities and synthesisMicrobial Natural Products and Biosynthesis