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Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors

Gang Liu, Prasenjit Mondal, Na Sang, Zihua Li, Weihua Ding, Liuyue Yang, Yan Liu, Vishal C. Birar, Ashley Gomm, Rudolph E. Tanzi, Can Zhang, Shiqian Shen, Changning Wang, Xiaoxia Lü, Ping Bai

2023European Journal of Medicinal Chemistry14 citationsDOIOpen Access PDF

Topics & Concepts

NeuroinflammationHDAC6ChemistryMicrogliaIn vivoPharmacologyInflammationBiodistributionHistone deacetylaseIn vitroBiochemistryCancer researchImmunologyHistoneBiologyBiotechnologyGeneHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisAdenosine and Purinergic Signaling
Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors | Litcius