Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro)
Kuojun Zhang, Tianyu Wang, Maotian Li, Mu Liu, He Tang, Lin Wang, Ke Ye, Jiamei Yang, Sheng Jiang, Yibei Xiao, Youhua Xie, Meiling Lü, Xiangyu Zhang
Topics & Concepts
ChemistryBaicaleinVero cellProteaseIC50PharmacologyDrugCoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Drug discoveryStructure–activity relationshipCoronavirus disease 2019 (COVID-19)StereochemistryEnzymeBiochemistryIn vitroBiologyMedicineInfectious disease (medical specialty)DiseasePathologyQuinazolinone synthesis and applicationsComputational Drug Discovery MethodsSynthesis and biological activity