Targeting monoamine oxidase A for T cell–based cancer immunotherapy
Xi Wang, Bo Li, Kwang Gi Kim, Yu-Chen Wang, Zhe Li, Jiaji Yu, Samuel Zeng, Xiaoya Ma, In Young Choi, Stefano Di Biase, Drake J. Smith, Yang Zhou, Yan-Ruide Li, Feiyang Ma, Jie Huang, Nicole Clarke, Angela To, Laura Gong, Alexander Pham, Heesung Moon, Matteo Pellegrini, Lili Yang
Abstract
expression with T cell dysfunction and decreased patient survival in a broad range of cancers. We further demonstrated that MAO-A restrains antitumor T cell immunity through controlling intratumoral T cell autocrine serotonin signaling. Together, these data identify MAO-A as an immune checkpoint and support repurposing MAOI antidepressants for cancer immunotherapy.
Topics & Concepts
ImmunotherapyMonoamine oxidaseCancer immunotherapyCancer researchCancerMedicineBiologyChemistryEnzymeBiochemistryInternal medicineCAR-T cell therapy researchImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers