Derivation and Application of Molecular Signatures to Prostate Cancer: Opportunities and Challenges
Dimitrios Doultsinos, Ian G. Mills
Abstract
Prostate cancer is a high-incidence cancer that requires improved patient stratification to ensure accurate predictions of risk and treatment response. Due to the significant contributions of transcription factors and epigenetic regulators to prostate cancer progression, there has been considerable progress made in developing gene signatures that may achieve this. Some of these are aligned to activities of key drivers such as the androgen receptor, whilst others are more agnostic. In this review, we present an overview of these signatures, the strategies for their derivation, and future perspectives on their continued development and evolution.
Topics & Concepts
Prostate cancerAndrogen receptorEpigeneticsRisk stratificationProstateKey (lock)Computational biologyComputer scienceCancerTranscription factorMedicineBioinformaticsData scienceBiologyRisk analysis (engineering)GeneInternal medicineComputer securityGeneticsProstate Cancer Treatment and ResearchUbiquitin and proteasome pathwaysCancer, Lipids, and Metabolism