Effect of Glucagon-Like Peptide-1 Receptor Agonists Administration During Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis of Randomized Control Trials
Abeline R. Watkins, Nicholas M. Fialka, Ryaan EL‐Andari, Jimmy J.H. Kang, Sabin J. Bozso, Jeevan Nagendran
Abstract
Aim: To determine if glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can benefit patients receiving coronary artery bypass graft (CABG), GLP-1 RAs administration alongside standard insulin was compared with perioperative insulin alone. Materials & methods: All articles from Pubmed and Scopus databases that compared GLP-1 RA administration to insulin alone during CABG were included for meta-analysis. Short-term postoperative outcomes were analyzed between groups. Results: Average postoperative blood glucose levels significantly favored GLP-1 RA with a mean difference of -0.72 (p < 0.001). No other variables were significantly different between GLP-1 RA and insulin alone. Conclusion: GLP-1 RA is a safe option for perioperative care of CABG patients that can potentially improve postoperative outcomes of CABG patients by improving glycemic control and reducing hyperglycemic episodes.