Recognizing Atypical Dopa-Responsive Dystonia and Its Mimics
Philippe A. Salles, Mérida Terán-Jimenez, Alvaro Vidal-Santoro, Pedro Chaná‐Cuevas, Marcelo Kauffman, Alberto J. Espay
Abstract
PURPOSE OF REVIEW: )-associated DRD consists of early-onset lower limb asymmetrical dystonia, with sleep benefit, diurnal variation, and excellent and sustained response to low l-dopa doses. RECENT FINDINGS: -associated late-onset DRD case with a family history of parkinsonism and cervical dystonia whose response to levodopa was poor and complicated with dyskinesia, blepharospasm, and severe nonmotor symptoms. We use this case as a springboard to review the spectrum of atypical DRD, DRD-plus, and DRD mimics. SUMMARY: variants have been found to be associated with Parkinson disease. Clinicians should be aware of atypical DRD, DRD-plus, and DRD mimics.