Discovery and structure–activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors
Amanda Lyons, James D. Kirkham, Kevin Blades, David Orr, Elizabeth M. Dauncey, Oliver H. Smith, Emma Dick, Rolf Walker, Teresa Matthews, Adam Bunt, Jonathan Finlayson, Ian M. Morrison, Victoria J. Savage, Emmanuel Moyo, Hayley S. Butler, Rebecca Newman, Nicola Ooi, Andrew Smith, Cédric Charrier, Andrew J. Ratcliffe, Neil R. Stokes, Stuart A. Best, Anne‐Marie Salisbury, Mark Craighead, Ian R. Cooper
Topics & Concepts
Topoisomerase IVhERGTopoisomeraseBroad spectrumIn vivoChemistryMultiple drug resistancePseudomonas aeruginosaIn vitroAntibacterial agentAntibioticsStructure–activity relationshipPharmacologyDNA gyraseMicrobiologyBacteriaEscherichia coliBiochemistryBiologyCombinatorial chemistryGeneticsPotassium channelGeneBiophysicsCancer therapeutics and mechanismsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and Efficacy