Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 cells
H. Zhang, Ming Li, Xueming Zhou, Li Tang, Guang‐Ying Chen, Yongmin Zhang, Yongmin Zhang
Topics & Concepts
ChemistryCombretastatinAutophagyA549 cellApoptosisCell cycle checkpointPiperazineCell cultureCell cycleTubulinCytotoxic T cellIn vivoCell growthIn vitroCell biologyMicrotubuleBiochemistryBiologyBiotechnologyGeneticsOrganic chemistryAutophagy in Disease and TherapyClick Chemistry and ApplicationsUbiquitin and proteasome pathways