New insights into the disulfide bond formation enzymes in epidithiodiketopiperazine alkaloids
Huan Liu, Jie Fan, Peng Zhang, Youcai Hu, Xingzhong Liu, Shu‐Ming Li, Wen‐Bing Yin
Abstract
A FAD-dependent oxidoreductase TdaR was responsible for α, β-disulfide formation in the biosynthesis of pretrichodermamide A. TdaR, together with its homologs AclT and GliT, catalysed not only α, α- but also α, β-disulfide formation in fungi.
Topics & Concepts
Disulfide bondOxidoreductaseBiosynthesisChemistryEnzymeStereochemistryBiochemistryMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsMycotoxins in Agriculture and Food