Nickel-Catalyzed Cross-Coupling Reaction of Aryl Methyl Sulfides with Aryl Bromides
Chuntao Zhong, Mengna Liu, Xianchao Qiu, Wei Hao, Benqiang Cui, Yanhui Shi, Changsheng Cao
Abstract
A nickel-catalyzed cross-coupling reaction of aryl methyl sulfides with aryl bromides has been developed to access biaryls in yields of up to 86%. The reactions proceeded well using Ni(COD) 2 as catalyst with the ligand BINAP (2,2′-bis(diphenylphosphanyl)-1,1′-binaphthalene) in the presence of magnesium. The method has a broad scope of substrates and is scalable. The wide availability of commercially available aryl bromides and the absence of preparation and preparation of organometallic reagents make the reaction of high application value.
Topics & Concepts
ArylNickelCatalysisCoupling reactionChemistryCoupling (piping)Medicinal chemistryOrganic chemistryMaterials scienceMetallurgyAlkylSulfur-Based Synthesis TechniquesCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods