VgrG Spike Dictates PAAR Requirement for the Assembly of the Type VI Secretion System
Xiaoye Liang, Hao‐Yu Zheng, Yajie Zhao, Yiqiu Zhang, Tong‐Tong Pei, Yang Cui, Ming‐Xuan Tang, Ping Xu, Tao Dong
Abstract
Gram-negative bacteria often encode multiple paralogs of the cone-shaped PAAR that sits atop the VgrG-spike and is thought to sharpen the spear-like T6SS puncturing device. However, it is unclear why PAAR is required for the assembly of some but not all T6SSs and why there are multiple PAARs if they are not required. Our data delineate a VgrG-mediated conditional requirement for PAAR and suggest a core-auxiliary relationship among different PAAR-VgrG modules that may have been acquired sequentially by the T6SS during evolution.
Topics & Concepts
BiologySecretionSpike (software development)Type VI secretion systemType (biology)MicrobiologyComputational biologyBiochemistryComputer scienceEcologyGeneVirulenceSoftware engineeringVibrio bacteria research studies