CuS@PDA–FA nanocomposites: a dual stimuli-responsive DOX delivery vehicle with ultrahigh loading level for synergistic photothermal–chemotherapies on breast cancer
Shang-Qing Zhang, Xun Liu, Qixuan Sun, Omar Johnson, Ting Yang, Mingli Chen, Jianhua Wang, Wei Chen
Abstract
) and a greater photothermal conversion efficiency (η = 42.7%) than CuS/PDA alone. The uptake of CuS@PDA-FA/DOX nanocomposites is much higher in MCF-7 cells than in A549 cells because MCF-7 cells have much higher folic acid receptors than A549. Under near infrared (NIR) irradiation, the CuS@PDA-FA/DOX system using a synergistic combination of photothermal therapy and chemotherapy yields a better therapeutic effect than either photothermal therapy or chemotherapy alone. The treatment is very effective with the cell viability is only 5.6 ± 1.4%.
Topics & Concepts
Photothermal therapyDoxorubicinPhotothermal effectNanocompositeMaterials scienceFolate receptorCopper sulfideChemotherapyDrug deliveryCancer cellCancer researchNanotechnologyCancerCopperMedicineSurgeryInternal medicineMetallurgyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryGraphene and Nanomaterials Applications