Identification of a Novel Hybrid Plasmid Encoding KPC-2 and Virulence Factors in Klebsiella pneumoniae Sequence Type 11
Longyang Jin, Ruobing Wang, Hua Gao, Qi Wang, Hui Wang
Abstract
Recent emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) coharboring bla KPC-2 and pLVPK-like virulence plasmids represented a novel clinical challenge. In the present study, we characterized a bla KPC-2 and virulence hybrid plasmid, designated pCRHV-C2244, from a clinical ST11-K64 CRKP strain. pCRHV-C2244 was non-self-transmissible due to incomplete conjugative elements but mobilizable together with a conjugative helper.
Topics & Concepts
VirulenceKlebsiella pneumoniaePlasmidBiologyMicrobiologyVirologyGeneticsGeneEscherichia coliAntibiotic Resistance in BacteriaAntimicrobial Resistance in StaphylococcusInfections and bacterial resistance