The Vaginal Microbiome of Nonhuman Primates Can Be Only Transiently Altered to Become <i>Lactobacillus</i> Dominant without Reducing Inflammation
Charlotte A. Langner, Alexandra M. Ortiz, Jacob K. Flynn, Heather Kendall, Laurel A. Lagenaur, Jason M. Brenchley
Abstract
dominance of the vaginal microbiome is unique to humans and remains an important risk factor in reproductive health. By assessing the extent to which NHPs can be colonized with exogenously applied L. crispatus to resemble a human vaginal microbiome and examining the effects on the vaginal microenvironment, we highlight the utility of NHPs in analysis of vaginal microbiome manipulations in the context of human disease.
Topics & Concepts
Lactobacillus crispatusLactobacillus gasseriMicrobiomeLactobacillusBiologyDysbiosisColonizationMicrobiologyMacaqueImmunologyEcologyBacteriaBioinformaticsGeneticsReproductive tract infections researchGut microbiota and healthCervical Cancer and HPV Research