Beneficial Effect of Grinting Grass (Cynodon dactylon) on the Streptozotocin Induced Diabetes Mellitus in the Mice
Martia Rani Tacharina, Arif Nur Muhammad Ansori, Hani Plumeriastuti, Kusnoto Kusnoto, Rochmah Kurnijasanti, Eka Pramyrtha Hestianah
Abstract
The aim of this study was to investigate antidiabetic activity of the non-polisacharide fraction of the aquoeus extract of printing grass (NPF-GG) in streptozotocin induced diabetes in mice. Thirty male BALB/C mice of two months age were divided into five gruops: placebo control, metformin control, NPF-GG treated gruops(250 mg/kgBW, 500 mg/kgBW, and 1000 mg/kgBW, respectively). Hypoglicemic effect and histopathological features of the pancreatic islet showed that NPF-GG have high antidiabetic effect. It induced hypoglicemic effect and increased the call quantity in Langerhans cells in the pancreas Keyword: antihyperglicemic activity, Cynodon dactylon, diabetes mellitus, pancreatic islet