Anodic oxidation triggered divergent 1,2- and 1,4-group transfer reactions of β-hydroxycarboxylic acids enabled by electrochemical regulation
Zhenxing Zhang, Lei Zhang, Xianhao Zhang, Jianxin Yang, Yunxing Yin, Yangye Jiang, Cheng‐Chu Zeng, Gang Lü, Yang Yang, Fanyang Mo
Abstract
a radical mechanism. In contrast to previously reported radical group transfer reactions, this 1,4-group transfer process features the migration of electron-rich aryl substituents. Furthermore, with these chemoselective electrochemical oxidation protocols, a range of ketones and β-keto esters including those possessing a challenging-to-access medium-sized ring could be synthesized in excellent yields.
Topics & Concepts
ElectrochemistryAnodic oxidationChemistryGroup (periodic table)Combinatorial chemistryOrganic chemistryElectrodePhysical chemistryRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization Methods