Synthesis of novel immunomodulatory 1,4-disubstituted bis-1,2,3-triazoles by using click chemistry and their intracellular mechanism of action
Yahya Nural, Irem Zehra Acar, Derya Yetkin, Çağla Efeoğlu, Zeynel Seferoğlu, Furkan Ayaz
Topics & Concepts
ChemistryClick chemistryAcetamideTriazoleIntracellularMechanism of actionFlow cytometry1,2,3-TriazoleProinflammatory cytokineStereochemistryTumor necrosis factor alphaCombinatorial chemistryIn vitroBiochemistryInflammationMolecular biologyOrganic chemistryImmunologyBiologyClick Chemistry and ApplicationsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity