Synaptic properties of the feedback connections from the thalamic reticular nucleus to the dorsal lateral geniculate nucleus
Peter W. Campbell, Gubbi Govindaiah, Sean P. Masterson, Martha E. Bickford, William Guido
Abstract
The thalamic reticular nucleus (TRN) modulates thalamocortical transmission through inhibition. In mouse, TRN terminals in the dorsal lateral geniculate nucleus (dLGN) form synapses with relay neurons but not interneurons. Stimulation of TRN terminals in dLGN leads to a frequency-dependent form of inhibition, with higher rates of stimulation leading to a greater suppression of spike firing. Thus, TRN inhibition appears more dynamic than previously recognized, having a graded rather than an all-or-none impact on thalamocortical transmission.
Topics & Concepts
Thalamic reticular nucleusNeuroscienceNucleusThalamusReticular connective tissueStimulationNeurotransmissionLateral geniculate nucleusDorsumBiologyReceptive fieldAnatomyVisual cortexBiochemistryReceptorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain functionPhotoreceptor and optogenetics research