Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells
Samuel W. Lukowski, Inga Rødahl, S. Thomas Kelly, Meihua Yu, James Gotley, Chenhao Zhou, Susan Millard, Stacey B. Andersen, Angelika N. Christ, Gabrielle T. Belz, Ian H. Frazer, Janin Chandra
Abstract
and lineage-mixed features characteristic to cDC1, cDC2, pDCs, and monocytes. In conclusion, these data suggest that multiple cDC cell states can co-express lineage-overlapping features, revealing a level of previously unappreciated cDC plasticity.
Topics & Concepts
Cyclin-dependent kinase 1BiologyPopulationCell biologyMitosisDendritic cellCellCell cultureCell cycleGeneticsAntigenDemographySociologyImmunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune cells in cancer