Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO<sub>3</sub>)<sub>3</sub>·9H<sub>2</sub>O
Kai Liu, Jiaolong Meng, Xuefeng Jiang
Abstract
Sulfoxides, as an essential pivot, are commonly found in pharmaceuticals and bulk chemicals. A practical synthetic protocol is depicted via application of readily obtainable Fe(NO 3 ) 3 ·9H 2 O as a catalyst and oxygen as a green oxidant for selective oxidation from thioethers to sulfoxides under ecofriendly and mild conditions. Various sulfoxides are all achieved in gram-scale with superior selectivity and efficiency. This protocol showcases broad-spectrum functional group compatibility, offering efficient access to sulfoxide construction for drug discovery and process optimization.
Topics & Concepts
SulfoxideCombinatorial chemistryCatalysisBroad spectrumChemistrySelectivityOxygenNanotechnologyOrganic chemistryMaterials scienceSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions